Hoth Therapeutics' Atopic Dermatitis Candidate Shows Improvement In Severity, Shares Jump - Hoth Therapeutics (NASDAQ:HOTH)


  • Hoth Therapeutics Inc HOTH announced Phase 1b trial data for BioLexa in adult patients with mild-to-moderate atopic dermatitis.
  • Using the SCORAD as a clinical tool for assessing the severity of atopic dermatitis (scale) and EASI score, a tool used to measure the extent (area) and severity of atopic eczema, all patients showed improvement during the study compared to the day one score. 
  • Using the EASI scale, 100% of patients showed clinically-relevant improvement >50% compared to Day 1 during the entire 28-day study treatment period. 
  • Also see: Hoth Therapeutics Shares Surge On Encouraging Preclinical Data From Alzheimer’s Program
  • Using SCORAD, 60% of patients showed overall clinically relevant improvement (>35% improvement) during the study compared to the Day 1 score. 
  • 42% of patients maintained improvement from day 14 to day 28, supporting the long-term effect of BioLexa.
  • A clinically relevant reduction in the total body surface area affected by atopic dermatitis was observed in 71% of patients treated with BioLexa. The total reduction of these patients ranged from 37.5% to 71.4%.
  • BioLexa was well tolerated, with no serious adverse events and no drug-related treatment-emergent adverse events observed.
  • Price Action: HOTH shares are up 25.2% at $7.13 on the last check Monday.


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